Description

Job Description

General Summary:

Our Seattle site is seeking a talented and motivated Protein Engineer (Senior Scientist) to join our dynamic team. If you are passionate about advancing scientific research and developing novel therapeutics, this role is for you!

Key Duties and Responsibilities:

Design and execute protein engineering/directed evolution campaigns to improve binding affinity, stability, and selectivity.

Utilize yeast surface display technology for library screening and directed evolution.

Drawing from a deep array of Rosetta scripts and machine learning tools, create computational design strategies to deliver protein drug candidates.

Effectively communicate design strategies to interdisciplinary team members.

Collaborate with cross-functional teams to optimize protein candidates for function, manufacturability, and immunogenicity.

Prepare reports, papers, and patent applications, collaborating closely with inventors, scientists, and legal counsel.

Knowledge and Skills:

Strong understanding of the biophysics of protein structure/function relationships

Proven experience in directed evolution, yeast surface display, and protein engineering.

Demonstrated proficiency in protein modeling and design utilizing Rosetta software suite, Alphafold2, ColabFold, Protein MPNN, RFdiffusion or equivalent tools for insilico protein engineering

Strong analytical skills and attention to detail

Excellent communication and teamwork abilities

Familiarity with antibody engineering and affinity maturation

Experience in cellular assay development

Understanding of cell biology and immunology

Education and Experience:

Ph.D. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 2-5 years of relevant post-doctoral, industry employment experience, or

M.S. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 5+ years of relevant industry employment experience, or

B.S. (or equivalent degree) in Computational Biology, Bioengineering, Chemical Engineering, or related field and 8+ years of relevant industry employment experience

This position will be based out of our Seattle site location focused on protein engineering for the organization. Over the past 9 years we have utilized protein engineering to create a robust pipeline including Acazicolcept (ALPN-101) and Povetacicept (ALPN-303)

#LI-BS1

Pay Range:
$116,000 - $174,000

Disclosure Statement:

The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations. From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

Flex Designation:
On-Site Designated

Flex Eligibility Status:

In thisOn-Sitedesignated role, you willworkfive days per week on-sitewith ad hoc flexibility.

Note:The Flex status for this position is subject to Vertex's Policy on Flex @ Vertex Program and may be changed at any time.

Company Information

Vertex is a global biotechnology company that invests in scientific innovation.

Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition atApplicationAssistance@vrtx.com