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Philadelphia, PA, United States
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Philadelphia, PA, United States
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University of Pennsylvania
Philadelphia, Pennsylvania, United States
18 days ago


Manager, Stability Programs (Gene Therapy Program)

University Overview

The University of Pennsylvania, the largest private employer in Philadelphia, is a world-renowned leader in education, research, and innovation. This historic, Ivy League school consistently ranks among the top 10 universities in the annual U.S. News & World Report survey. Penn has 12 highly-regarded schools that provide opportunities for undergraduate, graduate and continuing education, all influenced by Penn's distinctive interdisciplinary approach to scholarship and learning.

Penn offers a unique working environment within the city of Philadelphia. The University is situated on a beautiful urban campus, with easy access to a range of educational, cultural, and recreational activities. With its historical significance and landmarks, lively cultural offerings, and wide variety of atmospheres, Philadelphia is the perfect place to call home for work and play.

The University offers a competitive benefits package that includes excellent healthcare and tuition benefits for employees and their families, generous retirement benefits, a wide variety of professional development opportunities, supportive work and family benefits, a wealth of health and wellness programs and resources, and much more.

Posted Job Title
Manager, Stability Programs (Gene Therapy Program)

Job Profile Title
Manager C

Job Description Summary
The Gene Therapy Program (GTP) is entering a new era of unprecedented opportunity with the great potential to reshape the face of medicine as we know it. Our discoveries have set the stage for successful treatments and possibly even cures for devastating genetic diseases.

The laboratory of Dr. Jim Wilson, at GTP of the University of Pennsylvania, has been a leader in the development of innovative vector technology for close to three decades. We have emerged as the “go-to” organization for public and private partners, who want to participate in the gene therapy space. Currently, we are positioned to lead another round of vector innovation and establish pre-clinical and clinical proof-of-concept in therapeutic applications of in-vivo genome editing.

Continuation of all GTP positions is contingent upon funding.

Job Description

Our Vector Operations group, comprised of Manufacturing Sciences and Technology (MS&T), Analytical Sciences and Technology (AS&T) and External Manufacturing (EM) teams, provides manufacturing and analytical support of basic, translational and clinical research. The MS&T team is composed of teams that conduct platform development, process development and optimization, vector manufacturing and process technical transfer. The AS&T team conducts analytical development, quality control and assay technical transfer. The AS&T organization includes a molecular team, biochemical team, bioassay team, physical/chemical team and operations team that supports AS&T.

Due to significant growth, the Vector Core is looking for a new Manager of Stability Testing in the Analytics Operations team to support assay development and/or product characterization and release to support research, IND-enabling studies and clinical trials.

As a Manager you will manage projects, activities and/or new initiatives in either the molecular team, biochemical team, bioassay team, physical/chemical team or operations team. Examples of projects in each of the analytics teams include management of biodistribution studies in the molecular team, management of GxP testing in the biochemical team, management of automated systems in the bioassay team and management of stability programs in the operations team. In addition to managing projects or initiatives, you may also conduct testing while following new or established protocols or standard operating procedures (which may be conducted under GxP conditions) and emerge as a subject matter expert in either molecular, biochemical, cell-based or physical/chemical assays. If conducting testing, you will document your activities on test records or in a database and may be participating in the establishment of new information management systems. You may provide training for junior level staff on analytical testing methods and procedures and manage other laboratory activities. The Stability Manager will be managing the data associated with Stability programs, authoring and/or reviewing Stability protocols, generating Stability reports and contributing to regulatory submissions as needed.

You will work both independently and as part of a team to accomplish project goals within specified timelines. Successful candidates will have a familiarity with one or more of the following: mammalian cell culture, aseptic technique, molecular, biochemical, cell-based and/or physical/chemical assays. The techniques that are used across the vector analytics teams include qPCR, ddPCR, SDS-PAGE, ceSDS, Enzymatic Assays, ELISA, MSD, In-Cell Western, High Content Imaging, Analytical Ultracentrifugation, Size Exclusion Chromatography, Dynamic or Multi-Angle Light Scattering and Mass Spectrometry.

  • BS degree in chemistry, biology, chemical engineering or related disciplines with 5-7 years of experience required.
  • Must have experience with one or more of the following: molecular, biochemical, cell-based or physical/chemical techniques.
  • Prior experience managing programs (e.g. stability programs) desired.
  • Must be meticulous, detail oriented, and analytical.
  • Must be highly motivated, have excellent organizational, communication and interpersonal skills.
  • Must be able to work independently and as part of a multi-disciplinary team.

Job Location - City, State
Philadelphia, Pennsylvania

Department / School
Perelman School of Medicine

Pay Range
$50,684.00 - $91,232.00

Affirmative Action Statement
Penn adheres to a policy that prohibits discrimination on the basis of race, color, sex, sexual orientation, gender identity, religion, creed, national or ethnic origin, citizenship status, age, disability, veteran status, or any other legally protected class.

Special Requirements
Background check required after a conditional job offer is made. Consideration of the background check will be tailored to the requirements of the job.

University Benefits
  • Health, Life, and Flexible Spending Accounts: Penn offers comprehensive medical, prescription, behavioral health, dental, vision, and life insurance benefits to protect you and your family's health and welfare. You can also use flexible spending accounts to pay for eligible health care and dependent care expenses with pre-tax dollars.
  • Tuition: Take advantage of Penn's exceptional tuition benefits. You, your spouse, and your dependent children can get tuition assistance here at Penn. Your dependent children are also eligible for tuition assistance at other institutions.
  • Retirement: Penn offers generous retirement plans to help you save for your future. Penn's Basic, Matching, and Supplemental retirement plans allow you to save for retirement on a pre-tax or Roth basis. Choose from a wide variety of investment options through TIAA and Vanguard.
  • Time Away from Work: Penn provides you with a substantial amount of time away from work during the course of the year. This allows you to relax, take vacations, attend to personal affairs, recover from illness or injury, spend time with family-whatever your personal needs may be.
  • Long-Term Care Insurance: In partnership with Genworth Financial, Penn offers faculty and staff (and your eligible family members) long-term care insurance to help you cover some of the costs of long-term care services received at home, in the community or in a nursing facility. If you apply when you're newly hired, you won't have to provide proof of good health or be subject to underwriting requirements. Eligible family members must always provide proof of good health and are subject to underwriting.
  • Wellness and Work-life Resources: Penn is committed to supporting our faculty and staff as they balance the competing demands of work and personal life. That's why we offer a wide variety of programs and resources to help you care for your health, your family, and your work-life balance.
  • Professional and Personal Development: Penn provides an array of resources to help you advance yourself personally and professionally.
  • University Resources: As a member of the Penn community, you have access to a wide range of University resources as well as cultural and recreational activities. Take advantage of the University's libraries and athletic facilities, or visit our arboretum and art galleries. There's always something going on at Penn, whether it's a new exhibit at the Penn Museum, the latest music or theater presentation at the Annenberg Center, or the Penn Relays at Franklin Field to name just a few examples. As a member of the Penn community, you're right in the middle of the excitement-and you and your family can enjoy many of these activities for free.
  • Discounts and Special Services: From arts and entertainment to transportation and mortgages, you'll find great deals for University faculty and staff. Not only do Penn arts and cultural centers and museums offer free and discounted admission and memberships to faculty and staff. You can also enjoy substantial savings on other goods and services such as new cars from Ford and General Motors, cellular phone service plans, movie tickets, and admission to theme parks.
  • Flexible Work Hours: Flexible work options offer creative approaches for completing work while promoting balance between work and personal commitments. These approaches involve use of non-traditional work hours, locations, and/or job structures.
  • Penn Home Ownership Services: Penn offers a forgivable loan for eligible employees interested in buying a home or currently residing in West Philadelphia, which can be used for closing costs or home improvements.
  • Adoption Assistance: Penn will reimburse eligible employees on qualified expenses in connection with the legal adoption of an eligible child, such as travel or court fees, for up to two adoptions in your household.

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Job Information

  • Job ID: 59814962
  • Location:
    Philadelphia, Pennsylvania, United States
  • Company Name: University of Pennsylvania
  • Position Title: Manager, Stability Programs (Gene Therapy Program)
  • Job Function: Medical
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